| Id: | acc4423 |
| Group: | 1sens |
| Protein: | TRPV1 |
| Gene Symbol: | Trpv1 |
| Protein Id: | O35433 |
| Protein Name: | TRPV1_RAT |
| PTM: | phosphorylation |
| Site: | Ser502 |
| Site Sequence: | IQYFLQRRPSLKSLFVDSYSE |
| Disease Category: | Digestive system diseases |
| Disease: | Colitis |
| Disease Subtype: | Ulcerative colitis |
| Disease Cellline: | HEK293 |
| Disease Info: | |
| Drug: | Curcumin |
| Drug Info: | "Curcumin is a natural polyphenol compound commonly found in turmeric, known for its anti - inflammatory and antioxidant properties." |
| Effect: | modulate |
| Effect Info: | "In a rat model of ulcerative colitis, oral administration of curcumin can alleviate visceral hypersensitivity by inhibiting the phosphorylation of TRPV1 protein." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28812431 |
| Sentence Index: | 28812431_0 |
| Sentence: | Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis. |
Sequence & Structure:
MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASPLDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
