| Id: | acc4442 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P31750 |
| Protein Name: | AKT1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr308 |
| Site Sequence: | GIKDGATMKTFCGTPEYLAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Alcoholic Fatty Liver |
| Disease Subtype: | |
| Disease Cellline: | HepG2（还有小鼠实验） |
| Disease Info: | |
| Drug: | N-acetyl-L-cysteine (NAC) |
| Drug Info: | N-acetyl-L-cysteine (NAC) is a form of the amino acid cysteine and is used as a mucolytic agent to treat respiratory conditions by thinning mucus. It also has antioxidant properties. |
| Effect: | modulate |
| Effect Info: | Reduced phosphorylation of Akt may be associated with alcoholic fatty liver (AFL). NAC attenuates chronic ethanol-induced hepatic fat accumulation and the decrease in Akt phosphorylation at Thr308. Activation of Akt by insulin-like growth factor-1 (IGF-1) can significantly alleviate chronic ethanol-induced fatty liver in mice. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 28987868 |
| Sentence Index: | 28987868_7 |
| Sentence: | "Interestingly, N-acetyl-L-cysteine (NAC) significantly attenuated chronic ethanol-induced hepatic fat accumulation and the decline of Akt phosphorylation at Thr308." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 308 | U | Prostate cancer | Phosphorylation | 37384528 |
| T | 308 | U | Hepatocellular carcinoma | Phosphorylation | 33500384 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
