| Id: | acc4445 |
| Group: | 1sens |
| Protein: | CREB |
| Gene Symbol: | Creb1 |
| Protein Id: | Q01147 |
| Protein Name: | CREB1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser133 |
| Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
| Disease Category: | Nervous system diseases |
| Disease: | Alzheimer's Disease |
| Disease Subtype: | cognitive dysfunction |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | 1w·Cit |
| Drug Info: | "1w·Cit is a specific drug, although the details of its composition and properties are not clear from this single notation." |
| Effect: | modulate |
| Effect Info: | Dual-target AChE/PDE5 inhibitors enhance CREB phosphorylation and improve cognitive function in Alzheimer's disease. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29068218 |
| Sentence Index: | 29068218_3 |
| Sentence: | "Importantly, 1w Cit (citrate of 1w) could reverse the cognitive dysfunction of scopolamine-induced AD mice and exhibited an excellent effect on enhancing cAMP response element-binding protein (CREB) phosphorylation in vivo, a crucial factor in memory formation and synaptic plasticity." |
Sequence & Structure:
MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 133 | D | Type 2 diabetes | Phosphorylation | 34193609 |
| S | 133 | N | Heart failure | Phosphorylation | 17616745 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
