| Id: | acc4456 |
| Group: | 1sens |
| Protein: | cPLA2 |
| Gene Symbol: | Pla2g4a |
| Protein Id: | P50393 |
| Protein Name: | PA24A_RAT |
| PTM: | phosphorylation |
| Site: | Ser505 |
| Site Sequence: | LNLNTSYPLSPLRDFSPQDSF |
| Disease Category: | Immune system diseases |
| Disease: | Allergic |
| Disease Subtype: | |
| Disease Cellline: | RBL-2H3 |
| Disease Info: | |
| Drug: | Davallia mariesii extract (DRE) |
| Drug Info: | Davallia mariesii extract (DRE) is an extract derived from Davallia mariesii. It may have potential pharmacological activities. |
| Effect: | modulate |
| Effect Info: | "In the late stage of allergic reactions, DRE exerts its anti - allergic effect by inhibiting the phosphorylation of cPLA2 and the expression of its downstream COX - 2, thereby suppressing PGD2 synthesis. " |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29200667 |
| Sentence Index: | 29200667_8 |
| Sentence: | "In late allergic responses, DRE reduced PGD2 release and COX-2 expression and cPLA2 phosphorylation in FceRI-mediated mast cells." |
Sequence & Structure:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRRQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSTTLSSLKEKVSAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMTPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEDAEREYQNDNQASWVHRMLMALVSDSALFNTREGRAGKEHNFMLGLNLNTSYPLSPLRDFSPQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTAESI
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
