Id: acc4489
Group: 1sens
Protein: Smad3
Gene Symbol: Smad3
Protein Id: Q8BUN5
Protein Name: SMAD3_MOUSE
PTM: phosphorylation
Site: Ser425
Site Sequence: SPSIRCSSVS-----------
Disease Category: Cardiovascular and circulatory system diseases
Disease: Cardiac Fibrosis
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Rosmarinic acid
Drug Info: "Rosmarinic Acid is a natural phenolic compound that has antioxidant, anti - inflammatory, and antimicrobial properties. It is often found in plants such as rosemary and mint."
Effect: modulate
Effect Info: Rosmarinic acid (RA) alleviates cardiac fibrosis caused by long-term pressure overload through the AMPKα/Smad3 signaling pathway.
Note:
Score: 4.0
Pubmed(PMID): 29367637
Sentence Index:
Sentence:

Sequence & Structure:

MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 204 D Obesity Phosphorylation 29700281
- - D Chronic kidney disease Phosphorylation 23264657

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: