| Id: | acc4491 |
| Group: | 1sens |
| Protein: | Smad2 |
| Gene Symbol: | Smad2 |
| Protein Id: | O70436 |
| Protein Name: | SMAD2_RAT |
| PTM: | phosphorylation |
| Site: | Ser467 |
| Site Sequence: | SPSVRCSSMS----------- |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Unilateral Ureteral Obstruction |
| Disease Subtype: | |
| Disease Cellline: | / |
| Disease Info: | |
| Drug: | dietary iron restriction |
| Drug Info: | Dietary iron restriction refers to the limitation of iron intake in the diet. It is a non - pharmacological approach that may be used for certain medical conditions. |
| Effect: | modulate |
| Effect Info: | "In the rat model of unilateral ureteral obstruction (UUO), dietary iron intake restriction can reduce the phosphorylation level of Smad2 protein and alleviate renal fibrosis, indicating that the decrease in Smad2 phosphorylation is positively correlated with the therapeutic effect of this intervention." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29417224 |
| Sentence Index: | 29417224_12 |
| Sentence: | "Furthermore, dietary iron restriction decreased renal fibrosis, renal MMP-2 and MMP-9 activities, renal TGFbeta-RI expression, and Smad2 phosphorylation in rats with unilateral ureteral obstruction." |
Sequence & Structure:
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFSLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
