| Id: | acc4507 |
| Group: | 1sens |
| Protein: | CaMKII |
| Gene Symbol: | Camk2a |
| Protein Id: | P11798 |
| Protein Name: | KCC2A_MOUSE |
| PTM: | phosphorylation |
| Site: | Met282 |
| Site Sequence: | HRSTVASCMHRQETVDCLKKF |
| Disease Category: | Musculoskeletal system diseases |
| Disease: | Duchenne Muscular Dystrophy |
| Disease Subtype: | ventricular arrhythmia |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | genetic inhibition |
| Drug Info: | "Genetic inhibition refers to the process of suppressing or blocking genetic activity, often using drugs or other means to interfere with gene expression or function." |
| Effect: | inhibit |
| Effect Info: | "Site-directed mutagenesis can inhibit the oxidation of CaMKII, effectively prevent ventricular tachycardia in mdx mice, and improve abnormal calcium release events and action potentials in cardiomyocytes." |
| Note: | Non-conventional drugs |
| Score: | 4.5 |
| Pubmed(PMID): | 29654126 |
| Sentence Index: | 29654126_4 |
| Sentence: | "We hypothesized that genetic inhibition of CaMKII oxidation (ox-CaMKII) in a mouse model of Duchenne muscular dystrophy can alleviate abnormal Ca2+ homeostasis, thus, preventing ventricular arrhythmia." |
Sequence & Structure:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
