| Id: | acc4508 |
| Group: | 1sens |
| Protein: | TRAF6 |
| Gene Symbol: | Traf6 |
| Protein Id: | P70196 |
| Protein Name: | TRAF6_MOUSE |
| PTM: | ubiquitination |
| Site: | Lys63 |
| Site Sequence: | QGYDVEFDPPLESKYECPICL |
| Disease Category: | Respiratory system diseases |
| Disease: | Acute Lung Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Tabersonine? |
| Drug Info: | Tabersonine is a natural alkaloid with potential pharmacological activities. It may be involved in various biological processes. |
| Effect: | modulate |
| Effect Info: | "LPS stimulation leads to K63-linked polyubiquitination of TRAF6, activates the downstream NF-κB and p38 MAPK signaling pathways, and triggers an inflammatory response. Tabersonine can significantly inhibit the K63-linked polyubiquitination of TRAF6." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29746822 |
| Sentence Index: | 29746822_0 |
| Sentence: | Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. |
Sequence & Structure:
MSLLNCENSCGSSQSSSDCCAAMAASCSAAVKDDSVSGSASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
