| Id: | acc4511 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | Q5EG47 |
| Protein Name: | AAPK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Diabetic Tubulopathy |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Chloroquine + amodiaquine |
| Drug Info: | Chloroquine is an antimalarial drug used to prevent and treat malaria | Amodiaquine is also an antimalarial medicine often used for the treatment of malaria. |
| Effect: | modulate |
| Effect Info: | Chloroquine and amodiaquine enhanced the phosphorylation level of AMPK in diabetic renal tubular lesions. |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 29884802 |
| Sentence Index: | 29884802_0 |
| Sentence: | Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy. |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
