Id: acc4513
Group: 1sens
Protein: CaMKIIdelta
Gene Symbol: CAMK2D
Protein Id: Q13557
Protein Name: KCC2D_HUMAN
PTM: phosphorylation
Site: Thr287
Site Sequence: VASMMHRQETVDCLKKFNARR
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: type 2 diabetic heart
Disease Cellline:
Disease Info:
Drug: KN93
Drug Info: KN93 is a drug with specific pharmacological properties and potential applications in relevant medical research.
Effect: modulate
Effect Info: "In the right atrial appendages of diabetic rats and diabetic patients, the activity of calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is enhanced, leading to impaired cardiac systolic and diastolic functions. By using CaMKII inhibitors KN93 and AIP, it was found that CaMKII inhibition can partially or completely restore myocardial systolic and diastolic functions."
Note:
Score: 4.0
Pubmed(PMID): 29903013
Sentence Index:
Sentence:

Sequence & Structure:

MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CAMK2D-Thr287
Cancer Intensity
BRCA 0.062
COAD -0.012
HGSC 2.522
ccRCC 0.104
GBM -1.255
HNSC -0.12
LUAD 0.365
LUSC 0.381
non_ccRCC -0.196
PDAC -0.887
UCEC -0.964

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: