Id: acc4514
Group: 1sens
Protein: CaMKIIdelta
Gene Symbol: Camk2d
Protein Id: P15791
Protein Name: KCC2D_RAT
PTM: phosphorylation
Site: Thr287
Site Sequence: VASMMHRQETVDCLKKFNARR
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: type 2 diabetic heart
Disease Cellline:
Disease Info:
Drug: AIP
Drug Info: "AIP is a drug, which may have specific therapeutic effects and mechanisms of action in medical applications."
Effect: modulate
Effect Info: "In the right atrial appendages of diabetic rats and diabetic patients, the activity of calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is enhanced, leading to impaired cardiac systolic and diastolic functions. By using CaMKII inhibitors KN93 and AIP, it was found that CaMKII inhibition can partially or completely restore myocardial systolic and diastolic functions."
Note:
Score: 4.0
Pubmed(PMID): 29903013
Sentence Index:
Sentence:

Sequence & Structure:

MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: