| Id: | acc4519 |
| Group: | 1sens |
| Protein: | Smad3 |
| Gene Symbol: | Smad3 |
| Protein Id: | P84025 |
| Protein Name: | SMAD3_RAT |
| PTM: | phosphorylation |
| Site: | Ser423 |
| Site Sequence: | MGSPSIRCSSVS--------- |
| Disease Category: | Digestive system diseases |
| Disease: | Hepatic Fibrosis |
| Disease Subtype: | |
| Disease Cellline: | hepatic stellate cells |
| Disease Info: | |
| Drug: | TF-SC |
| Drug Info: | "TF - SC is a drug, but specific details about it are unknown from the given information." |
| Effect: | modulate |
| Effect Info: | TF-SC inhibits the phosphorylation of Smad3 and reduces the degree of liver fibrosis in rats. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29990830 |
| Sentence Index: | 29990830_0 |
| Sentence: | Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl4-induced hepatic fibrosis by modulating TGF-beta-induced Smad3 phosphorylation. |
Sequence & Structure:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
