| Id: | acc4527 |
| Group: | 1sens |
| Protein: | Src |
| Gene Symbol: | Src |
| Protein Id: | Q9WUD9 |
| Protein Name: | SRC_RAT |
| PTM: | phosphorylation |
| Site: | Tyr416 |
| Site Sequence: | DFGLARLIEDNEYTARQGAKF |
| Disease Category: | Nervous system diseases |
| Disease: | Dyskinetic |
| Disease Subtype: | levodopa-induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Tat-Src |
| Drug Info: | "Tat - Src is a drug, but detailed information about its specific properties and applications is not provided in the given context." |
| Effect: | modulate |
| Effect Info: | "Tat - Src also attenuated the S - nitrosylation (SNO - Src) and autophosphorylation (p - Src) of Src, thereby catalyzing the phosphorylation of NR2B. These findings suggest that targeting the NR2B/Src complex may be a potential therapeutic approach for motor disorders in Parkinson's disease." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30130562 |
| Sentence Index: | 30130562_0 |
| Sentence: | Tat-Src reduced NR2B tyrosine phosphorylation and its interaction with NR2B in levodopa-induced dyskinetic rats model. |
Sequence & Structure:
MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
