| Id: | acc4531 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk1 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Nervous system diseases |
| Disease: | Neuropathic Pain |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | dexmedetomidine |
| Drug Info: | "Dexmedetomidine is a medication used for sedation and analgesia, often in intensive care units or during certain medical procedures." |
| Effect: | modulate |
| Effect Info: | Dexmedetomidine alleviates neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in rats by inhibiting spinal ERK phosphorylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30181689 |
| Sentence Index: | 30181689_7 |
| Sentence: | Intrathecal administration of dexmedetomidine (2.5 microg) for 3 days not only attenuated neuropathic pain but also inhibited the CCI-induced P2X7R upregulation and ERK phosphorylation. |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
