| Id: | acc4542 |
| Group: | 1sens |
| Protein: | p38 MAPK |
| Gene Symbol: | Mapk14 |
| Protein Id: | P70618 |
| Protein Name: | MK14_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Immune system diseases |
| Disease: | Inflammatory |
| Disease Subtype: | carrageenan induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | prethanol extract of Trifolium pratense |
| Drug Info: | "Prethanol extract of Trifolium pratense is a botanical extract derived from Trifolium pratense, which may potentially have certain biological activities." |
| Effect: | modulate |
| Effect Info: | 40% PeTP reduces carrageenan-induced limb edema by inhibiting the activation of NF–κB and MAPK pathways. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30320514 |
| Sentence Index: | 30320514_3 |
| Sentence: | "Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 in RAW264.7 cells, without inducing cytotoxicity." |
Sequence & Structure:
MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
