| Id: | acc4567 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Nervous system diseases |
| Disease: | Central Nervous System Inflammation |
| Disease Subtype: | cognitive impairments |
| Disease Cellline: | PC12 |
| Disease Info: | |
| Drug: | salidroside |
| Drug Info: | "Salidroside is a natural compound with various pharmacological activities, such as anti - fatigue and anti - oxidative properties." |
| Effect: | modulate |
| Effect Info: | "Salidroside inhibits the phosphorylation of NF-κB p65 and IκBα by activating SIRT1 and regulates the phosphorylation of AMPK, thereby alleviating cognitive impairment caused by neuroinflammation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30848530 |
| Sentence Index: | 30848530_8 |
| Sentence: | "Besides, the expression of Sirt1, Nrf-2, HO-1, Bax, Bcl-2, caspase-9, and caspase-3 and the phosphorylation of AMPK, NF-kappaBp65, and IkappaBalpha were increased accompanying with the LPS-induced cognitive impairments, which were significantly suppressed by salidroside treatment." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
