| Id: | acc4571 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Mitochondrial Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | farrerol |
| Drug Info: | Farrerol is a natural compound with potential pharmacological activities. It may have certain effects in the field of medicine. |
| Effect: | modulate |
| Effect Info: | The drug alleviates the disease symptoms by reducing JNK phosphorylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30906210 |
| Sentence Index: | 30906210_6 |
| Sentence: | "Furthermore, farrerol effectively suppressed mitochondrial dysfunction by reducing JNK phosphorylation, Bax mitochondrial translocation, AIF and cytochrome c release." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
