| Id: | acc4572 |
| Group: | 1sens |
| Protein: | alpha-tubulin |
| Gene Symbol: | Tuba1b |
| Protein Id: | P05213 |
| Protein Name: | TBA1B_MOUSE |
| PTM: | acetylation |
| Site: | Lys40 |
| Site Sequence: | QPDGQMPSDKTIGGGDDSFNT |
| Disease Category: | Infectious diseases |
| Disease: | Bacterial Infection |
| Disease Subtype: | |
| Disease Cellline: | J774A.1 |
| Disease Info: | |
| Drug: | Evodiamine? |
| Drug Info: | "Evodiamine is a bioactive alkaloid with potential anti - tumor, anti - inflammatory and other pharmacological activities. " |
| Effect: | modulate |
| Effect Info: | "Evodiamine promotes the acetylation of α-tubulin around the microtubule organizing center, and facilitates the activation of the NLRP3 inflammasome and pyroptosis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30971927 |
| Sentence Index: | 30971927_8 |
| Sentence: | "Moreover, evodiamine administration evidently improved survival of mice with lethal bacterial infection, accompanied by increased production of IL-1beta and interferon-gamma, decreased bacterial load, and dampened liver inflammation." |
Sequence & Structure:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
