Id: acc4574
Group: 1sens
Protein: AMPK
Gene Symbol: Prkaa2
Protein Id: Q8BRK8
Protein Name: AAPK2_MOUSE
PTM: phosphorylation
Site: Thr172
Site Sequence: MMSDGEFLRTSCGSPNYAAPE
Disease Category: Digestive system diseases
Disease: Acute Liver Injury
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Thymoquinone (TQ)
Drug Info: "Thymoquinone (TQ) is a natural compound known for its potential health - promoting properties, such as anti - inflammatory and antioxidant effects."
Effect: modulate
Effect Info: TQ inhibits the activation of the PI3K/mTOR signaling pathway and activates AMPK phosphorylation.
Note:
Score: 4.0
Pubmed(PMID): 30974967
Sentence Index:
Sentence:

Sequence & Structure:

MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKACDIMAEVYRAMKQLGFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDSRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRARSSFDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 172 U Cardiomyopathy Phosphorylation 37733758

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: