Id: acc4584
Group: 1sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P31750
Protein Name: AKT1_MOUSE
PTM: phosphorylation
Site: Ser473
Site Sequence: ERRPHFPQFSYSASGTA----
Disease Category: Cardiovascular and circulatory system diseases
Disease: Myocardial Hypertrophy
Disease Subtype: Hsp22 OE
Disease Cellline:
Disease Info:
Drug: Tempol
Drug Info: Tempol is a drug that has antioxidant properties and may have potential applications in treating various conditions related to oxidative stress.
Effect: modulate
Effect Info: "Long-term Tempol treatment eliminated oxidative stress and the excessive production of reactive oxygen species (ROS), and reduced myocardial hypertrophy and Akt phosphorylation in TG mice. Tempol also significantly prolonged the lifespan of TG mice and prevented the appearance of senescence markers."
Note:
Score: 4.0
Pubmed(PMID): 31047988
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 473 D Alzheimer's disease Phosphorylation 35834993 ;  36843923
S 473 D Colonic inflammation Phosphorylation 36735734
S 473 D Diabetes mellitus Phosphorylation 17130464 ;  16777975 ;  15033922 ;  15033922 ;  16777975 ;  17130464 ;  35739993
S 473 D Turner syndrome Phosphorylation 33910978
S 473 U Cardiomyopathy Phosphorylation 35358489
S 473 U Diabetes mellitus Phosphorylation 35358489
S 473 U Endometrial cancer/carcinoma Phosphorylation 16585156
S 473 U Melanoma Phosphorylation 26565903
S 473 U Non-small cell lung cancer Phosphorylation 35961388
S 473 U Hepatocellular carcinoma Phosphorylation 33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: