| Id: | acc4585 |
| Group: | 1sens |
| Protein: | p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q04207 |
| Protein Name: | TF65_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser536 |
| Site Sequence: | SGDEDFSSIADMDFSALLSQI |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Damage |
| Disease Subtype: | |
| Disease Cellline: | BV-2 |
| Disease Info: | |
| Drug: | FTY720 |
| Drug Info: | FTY720 is a drug that has potential applications in the treatment of certain diseases. It may play a role in immunomodulation. |
| Effect: | modulate |
| Effect Info: | FTY720 reduces the phosphorylation of p65 and alleviates neuronal damage induced by microglial activation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31069623 |
| Sentence Index: | 31069623_12 |
| Sentence: | "Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage." |
Sequence & Structure:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
