| Id: | acc4587 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk10 |
| Protein Id: | Q61831 |
| Protein Name: | MK10_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Digestive system diseases |
| Disease: | Acute Liver Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | CAY10594 |
| Drug Info: | CAY10594 is a drug that may have specific pharmacological functions and applications in relevant research or medical fields. |
| Effect: | modulate |
| Effect Info: | "APAP induces an increase in JNK phosphorylation (activation), and JNK remains continuously active in the cytoplasm and mitochondria; CAY10594 can inhibit its persistent activation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31076618 |
| Sentence Index: | 31076618_6 |
| Sentence: | CAY10594 administration strongly blocked GSK-3beta (Serine 9)/JNK phosphorylation in the APAP-induced acute liver injury model. |
Sequence & Structure:
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
