Id: | acc4589 |
Group: | 1sens |
Protein: | AMPKalpha |
Gene Symbol: | Prkaa1 |
Protein Id: | Q5EG47 |
Protein Name: | AAPK1_MOUSE |
PTM: | phosphorylation |
Site: | Thr172 |
Site Sequence: | NAKIADFGLSNMMSDGEFLRT |
Disease Category: | Endocrine and metabolic diseases |
Disease: | Diabetes Mellitus |
Disease Subtype: | Type 1 Diabetes Mellitus |
Disease Cellline: | |
Disease Info: | |
Drug: | Metformin? |
Drug Info: | "Metformin is a widely - used drug for treating type 2 diabetes, which helps control blood sugar levels." |
Effect: | modulate |
Effect Info: | "Metformin activates AMPK, and then inhibits Th1/Th17 differentiation and promotes Treg generation by inhibiting mTOR." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 31105845 |
Sentence Index: | 31105845_8 |
Sentence: | Treatment of NOD mice with metformin significantly mitigated autoimmune insulitis and substantially decreased the number of pro-inflammatory IFN-gamma+ as well as IL17+ CD4 T cells in the spleens of NOD mice. |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.