Id: acc4591
Group: 1sens
Protein: MUS81
Gene Symbol: MUS81
Protein Id: Q96NY9
Protein Name: MUS81_HUMAN
PTM: phosphorylation
Site: Ser87
Site Sequence: DERLQRHRTSGGDHAPDSPSG
Disease Category: Other
Disease: Excessive Mitotic Abnormalities
Disease Subtype:
Disease Cellline: AG11395
Disease Info:
Drug: camptothecin
Drug Info: "Camptothecin is a natural alkaloid with anti - tumor properties, which can inhibit the activity of topoisomerase I."
Effect: modulate
Effect Info: "After camptothecin treatment, the loss of WRN exonuclease stimulates fork inactivation and the accumulation of parental gaps, thereby involving RAD51. This mechanism affects the enhancement of CHK1 phosphorylation and results in the persistence of RAD51 during treatment recovery. Notably, in WRN exonuclease - deficient cells, the persistence of RAD51 is associated with elevated mitotic phosphorylation of MUS81 at Ser87, which is crucial for preventing excessive mitotic abnormalities."
Note:
Score: 4.0
Pubmed(PMID): 31114910
Sentence Index:
Sentence:

Sequence & Structure:

MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: