| Id: | acc4592 |
| Group: | 1sens |
| Protein: | P38 |
| Gene Symbol: | Mapk14 |
| Protein Id: | P47811 |
| Protein Name: | MK14_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Loss |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | LPS |
| Drug Info: | "LPS, or lipopolysaccharide, is a large molecule consisting of a lipid and a polysaccharide that is a component of the outer membrane of Gram-negative bacteria." |
| Effect: | modulate |
| Effect Info: | "LPS increases the phosphorylation of p38 MAPK, the expression of TNF-α and IL-6, and neuronal loss." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31124385 |
| Sentence Index: | 31124385_9 |
| Sentence: | "About 1 mg/kg LPS via daily intraperitoneal (I.P.) injections for 12 days significantly increased p38 MAPK phosphorylation, TNF-alpha and IL-6 expression, and neuronal loss." |
Sequence & Structure:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
