| Id: | acc4599 |
| Group: | 1sens |
| Protein: | Akt2 |
| Gene Symbol: | Akt2 |
| Protein Id: | Q60823 |
| Protein Name: | AKT2_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser474 |
| Site Sequence: | DQRTHFPQFSYSASIRE---- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Obese |
| Disease Subtype: | hepatic metabolism and inflammation |
| Disease Cellline: | L02 |
| Disease Info: | |
| Drug: | Pituitary adenylate cyclase-activating polypeptide (PACAP) |
| Drug Info: | Pituitary adenylate cyclase - activating polypeptide (PACAP) is a neuropeptide that plays important roles in various physiological processes such as the regulation of the endocrine system and the nervous system. |
| Effect: | modulate |
| Effect Info: | "PACAP promotes the expression of FAIM protein. Overexpression of FAIM upregulates the phosphorylation of Akt2, alleviates inflammation, and reduces body weight and blood glucose levels." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31270932 |
| Sentence Index: | 31270932_7 |
| Sentence: | "Overexpression of FAIM down-regulated the expression of adipogenesis proteins, including SREBP1, SCD1, FAS, SREBP2 and HMGCR, and up-regulated glycogen synthesis proteins, including Akt2 (Ser474) phosphorylation, GLUT2 and GSK-3beta, in the liver of obese mice." |
Sequence & Structure:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTHFPQFSYSASIRE
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
