| Id: | acc4606 |
| Group: | 1sens |
| Protein: | cystathionine beta-synthase |
| Gene Symbol: | Cbs |
| Protein Id: | Q91WT9 |
| Protein Name: | CBS_MOUSE |
| PTM: | nitration |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Digestive system diseases |
| Disease: | Pancreatitis |
| Disease Subtype: | Acute Pancreatitis |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | ?S-adenosylmethionine |
| Drug Info: | "S-adenosylmethionine is a naturally occurring compound in the body, which plays important roles in various biochemical reactions such as methylation processes." |
| Effect: | modulate |
| Effect Info: | "SAM promotes the upregulation of iNOS (Nos2) and the tyrosine nitration modification of CBS, exacerbating pancreatitis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31539805 |
| Sentence Index: | 31539805_7 |
| Sentence: | S-adenosylmethionine administration enhanced Nos2 mRNA expression and cystathionine beta-synthase nitration and triggered homocysteine accumulation in acute pancreatitis. |
Sequence & Structure:
MPSGTSQCEDGSAGGFQHLDMHSEKRQLEKGPSGDKDRVWIRPDTPSRCTWQLGRAMADSPHYHTVLTKSPKILPDILRKIGNTPMVRINKISKNAGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERAGNLKPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDDTAEEILQQCDGKLDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPEGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDKWFKSNDEDSFAFARMLIAQEGLLCGGSSGSAMAVAVKAARELQEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEELSVKRPWWWRLRVQELSLSAPLTVLPTVTCEDTIAILREKGFDQAPVVNESGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPIHLTDTLGTLSHILEMDHFALVVHEQIQSRDQAWSGVVGGPTDCSNGMSSKQQMVFGVVTAIDLLNFVAAREQTQT
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
