| Id: | acc4607 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | P49185 |
| Protein Name: | MK08_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | RTAGTSFMMTPYVVTRYYRAP |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | "Diabetic Nephropathy, Renal fibrosis" |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | All-Trans Retinoic Acid |
| Drug Info: | All-Trans Retinoic Acid is a form of vitamin A that is used in the treatment of acute promyelocytic leukemia and some skin conditions. |
| Effect: | modulate |
| Effect Info: | "ATRA inhibits diabetes-induced JNK phosphorylation, and ATRA treatment improves diabetes-related symptoms." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31557800 |
| Sentence Index: | 31557800_8 |
| Sentence: | The diabetic condition decreased expression of retinoic acid receptor alpha (RAR-alpha) through phosphorylation in serine residues mediated by the activation of c-Jun N-terminal kinase (JNK). |
Sequence & Structure:
MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 183 | D | Alzheimer's disease | Phosphorylation | 23474850 |
| T | 183 | D | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
| T | 183 | U | Alzheimer's disease | Phosphorylation | 23474850 |
| T | 183 | U | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
