| Id: | acc4609 |
| Group: | 1sens |
| Protein: | Smad3 |
| Gene Symbol: | Smad3 |
| Protein Id: | P84025 |
| Protein Name: | SMAD3_RAT |
| PTM: | phosphorylation |
| Site: | Ser423 |
| Site Sequence: | MGSPSIRCSSVS--------- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | "Diabetic Nephropathy, Renal fibrosis" |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | All-Trans Retinoic Acid |
| Drug Info: | All-Trans Retinoic Acid is a form of vitamin A that is used in the treatment of acute promyelocytic leukemia and some skin conditions. |
| Effect: | modulate |
| Effect Info: | "ATRA inhibits diabetes-induced JNK phosphorylation, and ATRA treatment improves diabetes-related symptoms." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31557800 |
| Sentence Index: | 31557800_8 |
| Sentence: | The diabetic condition decreased expression of retinoic acid receptor alpha (RAR-alpha) through phosphorylation in serine residues mediated by the activation of c-Jun N-terminal kinase (JNK). |
Sequence & Structure:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
