| Id: | acc4621 |
| Group: | 1sens |
| Protein: | ACC |
| Gene Symbol: | ACACA |
| Protein Id: | Q13085 |
| Protein Name: | ACACA_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser79 |
| Site Sequence: | GLALHIRSSMSGLHLVKQGRD |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Hepatic Steatosis |
| Disease Subtype: | |
| Disease Cellline: | HepG2 |
| Disease Info: | |
| Drug: | PCW |
| Drug Info: | PCW is a drug. It may have specific pharmacological effects and uses in medical practice. |
| Effect: | modulate |
| Effect Info: | "The three main components in PCW, Poricoic acid, Pachymic acid, and Ergosterol, in cell experiments → ↑ phosphorylation of AMPK, ↑ phosphorylation of ACC, ↑ phosphorylation of SREBP1c, ↓ phosphorylation of mTOR, ↓ phosphorylation of P70S6K → Alleviate hepatic steatosis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 31569635 |
| Sentence Index: | 31569635_10 |
| Sentence: | "Three compounds present in PCW including poricoic acid, pachymic acid, and ergosterol, significantly decreased FFA-induced increase in intracellular TG levels, consistent with increased AMPK phosphorylation, suggesting that poricoic acid, pachymic acid, and ergosterol are responsible for PCW-mediated amelioration of hepatic steatosis." |
Sequence & Structure:
MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILSTMDSPST
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| ACACA-Ser114 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| ACACA-Ser115 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.551 |
| HGSC | 2.002 |
| ccRCC | -0.121 |
| GBM | |
| HNSC | -0.422 |
| LUAD | -0.657 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.252 |
| ACACA-Ser117 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.359 |
| COAD | -0.987 |
| HGSC | 2.245 |
| ccRCC | -0.32 |
| GBM | 0.34 |
| HNSC | -0.76 |
| LUAD | -0.983 |
| LUSC | -0.091 |
| non_ccRCC | 1.36 |
| PDAC | 0.042 |
| UCEC | -0.486 |
| ACACA-Ser1296 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | |
| ccRCC | |
| GBM | -0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| ACACA-Ser133 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.393 |
| COAD | -0.649 |
| HGSC | |
| ccRCC | -0.373 |
| GBM | 0.932 |
| HNSC | 0.59 |
| LUAD | -0.815 |
| LUSC | -0.572 |
| non_ccRCC | 1.729 |
| PDAC | |
| UCEC | 0.552 |
| ACACA-Ser60 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.861 |
| HGSC | -1.112 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.829 |
| LUSC | |
| non_ccRCC | -0.578 |
| PDAC | |
| UCEC | |
| ACACA-Ser62 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.324 |
| HGSC | 0.699 |
| ccRCC | |
| GBM | 0.054 |
| HNSC | 1.783 |
| LUAD | -0.918 |
| LUSC | |
| non_ccRCC | -0.125 |
| PDAC | |
| UCEC | -1.169 |
| ACACA-Ser66 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.591 |
| COAD | -0.164 |
| HGSC | -1.093 |
| ccRCC | 0.441 |
| GBM | -0.153 |
| HNSC | 1.181 |
| LUAD | -0.386 |
| LUSC | 1.028 |
| non_ccRCC | 1.804 |
| PDAC | -1.365 |
| UCEC | -0.701 |
| ACACA-Ser872 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
| ACACA-Thr647 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.199 |
| HGSC | |
| ccRCC | 1.378 |
| GBM | -1.421 |
| HNSC | |
| LUAD | -0.379 |
| LUSC | -0.549 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.773 |
| ACACA-Thr870 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
