| Id: | acc4640 |
| Group: | 1sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Damage |
| Disease Subtype: | Hyperglycaemia |
| Disease Cellline: | H9c2 |
| Disease Info: | |
| Drug: | Metformin+N-Acetyl Cysteine |
| Drug Info: | Metformin is a widely - used drug for treating type 2 diabetes | N - Acetyl Cysteine is often used as an antioxidant and to treat acetaminophen overdose. |
| Effect: | modulate |
| Effect Info: | Combined therapy prevents hyperglycemia-induced cardiac injury by reducing lipid accumulation through increasing the phosphorylation of AMPK and AKT. |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 31766382 |
| Sentence Index: | 31766382_10 |
| Sentence: | "We observed that the combination treatment prevented hyperglycaemic-induced cardiac damage by increasing GLUT4 expression and mitigating lipid accumulation via phosphorylation of both AMPK and AKT, while decreasing nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), as well as protein kinase C (PKC), a known activator of insulin receptor substrate-1 (IRS-1), via phosphorylation at Ser307." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
