Id: acc4642
Group: 1sens
Protein: Drp1
Gene Symbol: Dnm1l
Protein Id: Q8K1M6
Protein Name: DNM1L_MOUSE
PTM: phosphorylation
Site: Ser616
Site Sequence: SKPIPIMPASPQKGHAVNLLD
Disease Category: Endocrine and metabolic diseases
Disease: Obese
Disease Subtype: insulin resistance
Disease Cellline:
Disease Info:
Drug: Quercetin
Drug Info: "Quercetin is a flavonoid antioxidant found in various fruits, vegetables, and grains, with potential health benefits such as anti - inflammatory and anti - oxidative effects."
Effect: modulate
Effect Info: Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting the phosphorylation of Drp1 at serine 616 and mitochondrial fragmentation in endothelial cells.
Note:
Score: 4.0
Pubmed(PMID): 31781748
Sentence Index:
Sentence:

Sequence & Structure:

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: