Id: acc4668
Group: 1sens
Protein: STAT3
Gene Symbol: Stat3
Protein Id: P52631
Protein Name: STAT3_RAT
PTM: phosphorylation
Site: Tyr705
Site Sequence: EADPGSAAPYLKTKFICVTPT
Disease Category: Respiratory system diseases
Disease: Acute Lung Injury
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: HSPH1 inhibitor(KNK437)
Drug Info: HSPH1 inhibitor(KNK437) is a drug that functions as an inhibitor of HSPH1. It is potentially used in research related to the biological effects of HSPH1 inhibition.
Effect: modulate
Effect Info: Activating the IL–1β/KLF2/HSPH1 pathway promotes the phosphorylation of STAT3 in AMs and exacerbates pulmonary inflammation in ALI.
Note:
Score: 4.0
Pubmed(PMID): 32091104
Sentence Index:
Sentence:

Sequence & Structure:

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVDLFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: