| Id: | acc4683 |
| Group: | 1sens |
| Protein: | JNK1 |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | RTAGTSFMMTPYVVTRYYRAP |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | High-Fat Diet |
| Disease Subtype: | |
| Disease Cellline: | MC-IXC |
| Disease Info: | |
| Drug: | chloroform fraction from Actinidia arguta |
| Drug Info: | The drug is a chloroform fraction extracted from Actinidia arguta. It may have certain biological activities and potential medical applications. |
| Effect: | modulate |
| Effect Info: | "CFAA restores the phosphorylation level of Akt inhibited by HFD, enhances anti - apoptotic signals, and improves neurological function." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32238886 |
| Sentence Index: | 32238886_5 |
| Sentence: | "In addition, in a molecular biology study, it was observed that CFAA improves HFD-induced abnormal insulin signaling such as increase of IRS phosphorylation at serine residues and reduction of Akt phosphorylation caused by the increase of JNK phosphorylation and then inhibited apoptosis." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
