| Id: | acc4686 |
| Group: | 1sens |
| Protein: | Smad3 |
| Gene Symbol: | Smad3 |
| Protein Id: | P84025 |
| Protein Name: | SMAD3_RAT |
| PTM: | phosphorylation |
| Site: | Ser425 |
| Site Sequence: | SPSIRCSSVS----------- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Cardiac Fibrosis |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | HC067047 |
| Drug Info: | "HC067047 is a drug, although specific details about it are not provided." |
| Effect: | modulate |
| Effect Info: | The TRPV4 antagonist HC067047 alleviates diabetes-induced cardiac fibrosis. HC067047 reduces the synthesis of collagen Ι and inhibits the level of transforming growth factor β 1 (TGF-β1) and the phosphorylation of Smad3 in the diabetic heart. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32274619 |
| Sentence Index: | 32274619_8 |
| Sentence: | "Furthermore, HC067047 reduced collagen Iota synthesis and suppressed the transforming growth factor beta 1 (TGF-beta1) level as well as the phosphorylation of Smad3 in the diabetic heart." |
Sequence & Structure:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
