| Id: | acc4688 |
| Group: | 1sens |
| Protein: | Drp1 |
| Gene Symbol: | Dnm1l |
| Protein Id: | Q8K1M6 |
| Protein Name: | DNM1L_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser616 |
| Site Sequence: | SKPIPIMPASPQKGHAVNLLD |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Injury |
| Disease Subtype: | |
| Disease Cellline: | NMVM |
| Disease Info: | |
| Drug: | doxorubicin |
| Drug Info: | Doxorubicin is an anthracycline antibiotic used in cancer chemotherapy to treat a wide range of cancers. |
| Effect: | inhibit |
| Effect Info: | The mitophagy inhibitor liensinine inhibits doxorubicin-induced cardiotoxicity by suppressing the phosphorylation of Drp1. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 32339784 |
| Sentence Index: | 32339784_7 |
| Sentence: | "LIEN treatment decreased Drp1 phosphorylation at Ser616 site, inhibited mitochondrial fragmentation, mitophagy (assessed by TOM20 and TIM23), oxidative stress, cytochrome C leakage, cardiomyocyte apoptosis, as well as improved mitochondrial function and cardiomyocyte contractile function in DOX-induced cardiac injury." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
