| Id: | acc4691 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr185 |
| Site Sequence: | AGTSFMMTPYVVTRYYRAPEV |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | myocardial infarction |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | melatonin |
| Drug Info: | Melatonin is a hormone that regulates the sleep - wake cycle and is commonly used as a sleep aid. |
| Effect: | modulate |
| Effect Info: | "Melatonin reduced the phosphorylation level of JNK in the hearts of the diabetic group after myocardial infarction, decreased the expression of p53, and inhibited apoptosis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32411318 |
| Sentence Index: | 32411318_7 |
| Sentence: | "Furthermore, melatonin decreased JNK phosphorylation, reduced p53 levels, and suppressed apoptosis in hearts from the post-MI diabetic group." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
