Id: acc4700
Group: 1sens
Protein: eNOS
Gene Symbol: NOS3
Protein Id: P29474
Protein Name: NOS3_HUMAN
PTM: phosphorylation
Site: Tyr81
Site Sequence: KNWEVGSITYDTLSAQAQQDG
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: Diabetic Endothelial Dysfunction
Disease Cellline:
Disease Info:
Drug: AKB-9778
Drug Info: AKB-9778 is a drug. It may have specific pharmacological effects and applications in the medical field.
Effect: modulate
Effect Info: VE - PTP inhibition significantly reduces systolic and diastolic blood pressure in diabetic patients and improves endothelial function by increasing the phosphorylation of endothelial nitric oxide synthase (eNOS) at Tyr81 and Ser1177.
Note:
Score: 4.0
Pubmed(PMID): 32653904
Sentence Index:
Sentence:

Sequence & Structure:

MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
NOS3 TILARGININE ACETATE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Terminated anemia (phenotype) ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Completed sickle cell anemia ClinicalTrials
ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Completed hyperlipidemia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Terminated HIV infection ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Withdrawn hypoxia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed serum lipopolysaccharide activity ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed sarcopenia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed breast cancer ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed sickle cell anemia ClinicalTrials
ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

NOS3-Ser114
Cancer Intensity
BRCA 0.49
COAD 0.793
HGSC 1.744
ccRCC 0.038
GBM 0.046
HNSC 0.481
LUAD -1.558
LUSC 0.7
non_ccRCC -1.385
PDAC -0.44
UCEC -0.908
NOS3-Ser1177
Cancer Intensity
BRCA 0.71
COAD 0.399
HGSC 1.182
ccRCC 0.059
GBM -0.83
HNSC 0.225
LUAD 0.965
LUSC 0.783
non_ccRCC -1.984
PDAC -0.216
UCEC -1.292
NOS3-Ser1179
Cancer Intensity
BRCA 0.841
COAD 0.511
HGSC -1.163
ccRCC 0.561
GBM
HNSC
LUAD 0.712
LUSC 0.986
non_ccRCC -1.897
PDAC -0.022
UCEC -0.531
NOS3-Ser1202
Cancer Intensity
BRCA
COAD 0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC -0.707
NOS3-Ser39
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser483
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.707
GBM
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser53
Cancer Intensity
BRCA
COAD -0.337
HGSC 1.385
ccRCC -0.066
GBM
HNSC
LUAD -0.982
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser56
Cancer Intensity
BRCA
COAD -0.707
HGSC
ccRCC 0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser57
Cancer Intensity
BRCA
COAD 0.707
HGSC
ccRCC -0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser615
Cancer Intensity
BRCA
COAD -0.974
HGSC 0.868
ccRCC -0.967
GBM
HNSC
LUAD -0.091
LUSC
non_ccRCC 1.164
PDAC
UCEC
NOS3-Ser617
Cancer Intensity
BRCA
COAD -0.627
HGSC 1.153
ccRCC -0.527
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser624
Cancer Intensity
BRCA
COAD 0.707
HGSC -0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser625
Cancer Intensity
BRCA
COAD 0.946
HGSC -1.046
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC 0.1
NOS3-Ser633
Cancer Intensity
BRCA
COAD -0.119
HGSC 1.85
ccRCC 0.021
GBM
HNSC 0.016
LUAD -0.891
LUSC
non_ccRCC
PDAC -0.877
UCEC
NOS3-Ser634
Cancer Intensity
BRCA
COAD -0.707
HGSC
ccRCC 0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS3-Ser638
Cancer Intensity
BRCA
COAD -1.15
HGSC
ccRCC 0.661
GBM
HNSC
LUAD
LUSC 0.49
non_ccRCC
PDAC
UCEC
NOS3-Ser836
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.615
GBM
HNSC
LUAD 1.256
LUSC
non_ccRCC -0.968
PDAC
UCEC 0.327
NOS3-Thr1175
Cancer Intensity
BRCA 0.582
COAD 0.281
HGSC 1.827
ccRCC -0.067
GBM -1.23
HNSC 0.078
LUAD 0.282
LUSC 0.653
non_ccRCC -2.023
PDAC -0.345
UCEC -0.036
NOS3-Thr33
Cancer Intensity
BRCA
COAD 0.551
HGSC 1.449
ccRCC 0.591
GBM
HNSC
LUAD -0.842
LUSC
non_ccRCC -0.944
PDAC
UCEC -0.805
NOS3-Thr636
Cancer Intensity
BRCA
COAD -0.617
HGSC 1.154
ccRCC -0.536
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: