Id: acc4701
Group: 1sens
Protein: eNOS
Gene Symbol: NOS3
Protein Id: P29474
Protein Name: NOS3_HUMAN
PTM: phosphorylation
Site: Ser1177
Site Sequence: EVTSRIRTQSFSLQERQLRGA
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: Diabetic Endothelial Dysfunction
Disease Cellline:
Disease Info:
Drug: AKB-9778
Drug Info: AKB-9778 is a drug. It may have specific pharmacological effects and applications in the medical field.
Effect: modulate
Effect Info: VE - PTP inhibition significantly reduces systolic and diastolic blood pressure in diabetic patients and improves endothelial function by increasing the phosphorylation of endothelial nitric oxide synthase (eNOS) at Tyr81 and Ser1177.
Note:
Score: 4.0
Pubmed(PMID): 32653904
Sentence Index:
Sentence:

Sequence & Structure:

MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
NOS3 TILARGININE ACETATE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Terminated anemia (phenotype) ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Completed sickle cell anemia ClinicalTrials
ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 2 Completed hyperlipidemia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Terminated HIV infection ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Withdrawn hypoxia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed serum lipopolysaccharide activity ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed sarcopenia ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed breast cancer ClinicalTrials
NOS3 TILARGININE Nitric oxide synthase inhibitor 1 Completed sickle cell anemia ClinicalTrials
ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
NOS3-Ser1177
Cancer Intensity
BRCA 0.71
COAD 0.399
HGSC 1.182
ccRCC 0.059
GBM -0.83
HNSC 0.225
LUAD 0.965
LUSC 0.783
non_ccRCC -1.984
PDAC -0.216
UCEC -1.292

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: