| Id: | acc4707 |
| Group: | 1sens |
| Protein: | PRDX3 |
| Gene Symbol: | PRDX3 |
| Protein Id: | P30048 |
| Protein Name: | PRDX3_HUMAN |
| PTM: | acetylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Beta-Cell Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | human beta cells (1.1B4) |
| Disease Info: | |
| Drug: | high glucose |
| Drug Info: | "High glucose refers to an elevated level of glucose in the blood, which is a crucial aspect in metabolic health assessment." |
| Effect: | modulate |
| Effect Info: | High glucose leads to mitochondrial dysfunction in pancreatic islet β-cells by promoting the acetylation of PRDX3. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32763411 |
| Sentence Index: | 32763411_12 |
| Sentence: | "Collectively, our results unveil a novel and first direct effect of high glucose on PRDX3 acetylation on beta-cell dysfunction by impaired antioxidant defense and SIRT1 mediated SIRT3-PRDX3 activation by Teneligliptin suppresses high glucose-mediated mitochondrial dysfunction." |
Sequence & Structure:
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| PRDX3-Lys241 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.518 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.635 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.153 |
| PRDX3-Lys253 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.866 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.753 |
| HNSC | |
| LUAD | |
| LUSC | 0.378 |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.241 |
| PRDX3-Lys83 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.403 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.468 |
| HNSC | |
| LUAD | 0.013 |
| LUSC | -0.802 |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.082 |
| PRDX3-Lys91 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.915 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -1.581 |
| HNSC | |
| LUAD | 0.772 |
| LUSC | 0.125 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.23 |
| PRDX3-Lys93 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
