| Id: | acc4708 |
| Group: | 1sens |
| Protein: | PRDX3 |
| Gene Symbol: | Prdx3 |
| Protein Id: | Q9Z0V6 |
| Protein Name: | PRDX3_RAT |
| PTM: | acetylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Beta-Cell Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | rat insulinoma INS-1?cells |
| Disease Info: | |
| Drug: | high glucose |
| Drug Info: | "High glucose refers to an elevated level of glucose in the blood, which is a crucial aspect in metabolic health assessment." |
| Effect: | modulate |
| Effect Info: | High glucose leads to mitochondrial dysfunction in pancreatic islet β-cells by promoting the acetylation of PRDX3. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32763411 |
| Sentence Index: | 32763411_12 |
| Sentence: | "Collectively, our results unveil a novel and first direct effect of high glucose on PRDX3 acetylation on beta-cell dysfunction by impaired antioxidant defense and SIRT1 mediated SIRT3-PRDX3 activation by Teneligliptin suppresses high glucose-mediated mitochondrial dysfunction." |
Sequence & Structure:
MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDMLWSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEEPLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
