| Id: | acc4713 |
| Group: | 1sens |
| Protein: | Connexin43 |
| Gene Symbol: | Gja1 |
| Protein Id: | P08050 |
| Protein Name: | CXA1_RAT |
| PTM: | phosphorylation |
| Site: | Ser368 |
| Site Sequence: | VDQRPSSRASSRASSRPRPDD |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Acute Myocardial Ischaemia and Reperfusion (I-R) |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Ursodeoxycholic acid (UDCA) |
| Drug Info: | Ursodeoxycholic acid (UDCA) is a bile acid that can dissolve gallstones and is used to treat certain liver diseases. |
| Effect: | modulate |
| Effect Info: | "Protect the phosphorylation state of Connexin43 under ischemic conditions, maintain gap junction function, alleviate conduction slowing, prolong the cardiac electrophysiological wavelength, and thereby reduce the occurrence of arrhythmia. Long - term administration of UDCA (2 weeks) can effectively maintain the phosphorylation level of Connexin43. " |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32943714 |
| Sentence Index: | 32943714_9 |
| Sentence: | "The antiarrhythmic effect of UDCA may be partially mediated by an increase in cardiac wavelength, due to the attenuation of conduction velocity slowing (p = 0.03), and the preservation of Connexin43 phosphorylation during acute ischaemia (p = 0.0027)." |
Sequence & Structure:
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
