Id: | acc4726 |
Group: | 1sens |
Protein: | JNK3 |
Gene Symbol: | Mapk10 |
Protein Id: | Q61831 |
Protein Name: | MK10_MOUSE |
PTM: | phosphorylation |
Site: | unclear |
Site Sequence: | |
Disease Category: | Nervous system diseases |
Disease: | Alzheimer's Disease |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | photobiomodulation (PBM) |
Drug Info: | Photobiomodulation (PBM) is a therapeutic technique that uses low - level light to stimulate biological processes in cells and tissues. It is non - invasive and has potential applications in various fields such as wound healing and pain management. |
Effect: | modulate |
Effect Info: | "Photobiomodulation significantly suppressed the phosphorylation level of JNK3 in the AD model. This effect is dependent on ERK-mediated MKP7 activation, which inhibits neurodegenerative signals, improves the function of AMPA receptors, and alleviates neuronal death and synaptic dysfunction by suppressing the phosphorylation of JNK3." |
Note: | Non-conventional drugs |
Score: | 3.0 |
Pubmed(PMID): | 33336891 |
Sentence Index: | 33336891_10 |
Sentence: | "Furthermore, activation of ERK/MKP7 signaling by PBM increased the level of AMPA receptor subunit GluR 1 phosphorylation and attenuated AMPA receptor endocytosis in an AD pathological model." |
Sequence & Structure:
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.