Id: acc4726
Group: 1sens
Protein: JNK3
Gene Symbol: Mapk10
Protein Id: Q61831
Protein Name: MK10_MOUSE
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Nervous system diseases
Disease: Alzheimer's Disease
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: photobiomodulation (PBM)
Drug Info: Photobiomodulation (PBM) is a therapeutic technique that uses low - level light to stimulate biological processes in cells and tissues. It is non - invasive and has potential applications in various fields such as wound healing and pain management.
Effect: modulate
Effect Info: "Photobiomodulation significantly suppressed the phosphorylation level of JNK3 in the AD model. This effect is dependent on ERK-mediated MKP7 activation, which inhibits neurodegenerative signals, improves the function of AMPA receptors, and alleviates neuronal death and synaptic dysfunction by suppressing the phosphorylation of JNK3."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 33336891
Sentence Index:
Sentence:

Sequence & Structure:

MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: