| Id: | acc4736 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk1 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | phosphorylation |
| Site: | Tyr187? |
| Site Sequence: | TCDLKICDFGLARIADPEHDH |
| Disease Category: | Digestive system diseases |
| Disease: | Colonic Hypersensitivity |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | linaclotide |
| Drug Info: | Linaclotide is a medication used for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. |
| Effect: | modulate |
| Effect Info: | Drugs inhibit stress-induced colonic hypersensitivity and ERK phosphorylation |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33373484 |
| Sentence Index: | 33373484_11 |
| Sentence: | "GC-C agonism attenuated stress-induced colonic hypersensitivity and ERK phosphorylation, but had no effect on CRF expression, suggesting the analgesic effects of linaclotide occur independent of stress-driven CRF gene expression in corticolimbic circuitry." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
