| Id: | acc4744 |
| Group: | 1sens |
| Protein: | PGC1alpha |
| Gene Symbol: | Ppargc1a |
| Protein Id: | Q9QYK2 |
| Protein Name: | PRGC1_RAT |
| PTM: | acetylation |
| Site: | Lys |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac and Neurological Injuries |
| Disease Subtype: | |
| Disease Cellline: | H9c2 |
| Disease Info: | |
| Drug: | ginsenoside Rc |
| Drug Info: | "Ginsenoside Rc is a type of ginsenoside, which is an active component found in ginseng and has various potential health - promoting effects." |
| Effect: | modulate |
| Effect Info: | Ginsenoside Rc reduces mitochondrial damage and apoptosis by decreasing PGC1α acetylation mediated by SIRT1 restoration. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33439015 |
| Sentence Index: | 33439015_9 |
| Sentence: | "More importantly, ginsenoside Rc reduces mitochondrial damage and apoptosis through SIRT1 restoration-mediated reduction of PGC1alpha acetylation in the I/R-induced cardiac and neuronal models." |
Sequence & Structure:
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGLFDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
