| Id: | acc4747 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nfkbia |
| Protein Id: | Q9Z1E3 |
| Protein Name: | IKBA_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser36 |
| Site Sequence: | DDRHDSGLDSMKDEEYEQMVK |
| Disease Category: | Digestive system diseases |
| Disease: | Colitis |
| Disease Subtype: | ulcerative colitis |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | coptisine?(COP) |
| Drug Info: | Coptisine (COP) is a bioactive compound that has been studied for its potential pharmacological properties. It may have various health - related effects. |
| Effect: | modulate |
| Effect Info: | COP treatment can improve colitis by inhibiting the phosphorylation of IκBα. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33508280 |
| Sentence Index: | 33508280_10 |
| Sentence: | "In addition, COP treatment remarkably suppressed the levels of colonic myeloperoxidase (MPO), adhesion molecules and pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-17), while enhanced IL-10 and TGF-beta." |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
