| Id: | acc4776 |
| Group: | 1sens |
| Protein: | GSK3beta |
| Gene Symbol: | Gsk3b |
| Protein Id: | Q9WV60 |
| Protein Name: | GSK3B_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser9 |
| Site Sequence: | -MSGRPRTTSFAESCKPVQQP |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Fatty Liver Disease |
| Disease Subtype: | Non-Alcoholic Fatty Liver Disease |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | OBB |
| Drug Info: | OBB is a drug. Further details about it may be required for a more comprehensive description. |
| Effect: | modulate |
| Effect Info: | The mechanism of action of OBB in treating NAFLD involves effectively improving insulin signaling disorders by regulating the phosphorylation state of the IRS-1/Akt/GSK-3β pathway. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33831691 |
| Sentence Index: | 33831691_9 |
| Sentence: | "OBB significantly inhibited aberrant phosphorylation of IRS-1 and up-regulated the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3beta/GSK-3beta) to improve hepatic insulin signal transduction." |
Sequence & Structure:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
