Id: acc4778
Group: 1sens
Protein: Creb1
Gene Symbol: Creb1
Protein Id: Q01147
Protein Name: CREB1_MOUSE
PTM: phosphorylation
Site: Ser133
Site Sequence: LNDLSSDAPGVPRIEEEKSEE
Disease Category: Endocrine and metabolic diseases
Disease: Hypoglycemia
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: glucose
Drug Info: "Glucose is a simple sugar that serves as a primary energy source for the body, often used in medical settings to treat hypoglycemia."
Effect: modulate
Effect Info: "Fgf15 is a key regulatory factor. Fgf15 neurons lead to enhanced sympathetic nerve activity, causing an increase in the phosphorylation level of Creb1 protein in the liver and ultimately resulting in glucose intolerance."
Note:
Score: 4.0
Pubmed(PMID): 33883213
Sentence Index:
Sentence:

Sequence & Structure:

MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 133 D Type 2 diabetes Phosphorylation 34193609
S 133 N Heart failure Phosphorylation 17616745

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: