| Id: | acc4785 |
| Group: | 1sens |
| Protein: | P38 |
| Gene Symbol: | Mapk14 |
| Protein Id: | P70618 |
| Protein Name: | MK14_RAT |
| PTM: | phosphorylation |
| Site: | Thr180 |
| Site Sequence: | LARHTDDEMTGYVATRWYRAP |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Subarachnoid Hemorrhage |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Hydrogen gas |
| Drug Info: | Hydrogen gas is a simple gaseous molecule. It has potential therapeutic effects in some medical applications. |
| Effect: | modulate |
| Effect Info: | "Hydrogen treatment downregulates SAH-induced p38 MAPK phosphorylation, alleviating neuronal pyroptosis and inflammatory responses." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34149882 |
| Sentence Index: | 34149882_7 |
| Sentence: | "Hydrogen gas post-conditioning significantly alleviated brain edema and improved neurologic function, reduced ROS production and neuronal pyroptosis, suppressed the expression of IL-1beta and IL-18 whilst upregulating ERK1/2 phosphorylation, but downregulated p38 MAPK activation 24 h post-SAH." |
Sequence & Structure:
MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
