Id: acc4789
Group: 1sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P31750
Protein Name: AKT1_MOUSE
PTM: phosphorylation
Site: Ser473
Site Sequence: ERRPHFPQFSYSASGTA----
Disease Category: Endocrine and metabolic diseases
Disease: Plasmalogen Deficiency
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: TDG
Drug Info: "TDG is a drug, but specific information about its nature, use and mechanism is not provided here."
Effect: modulate
Effect Info: Plasma phospholipid deficiency inhibits the activation of AKT. We found that inhibiting the phosphorylation of AKT at Ser473 and Thr308 was sufficient to induce the distal relocation of the AIS. Short-chain alkyl glycerols (such as TDG) can restore the synthesis of plasmalogens and reverse the distal displacement of the AIS.
Note:
Score: 4.0
Pubmed(PMID): 34302896
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 473 D Alzheimer's disease Phosphorylation 35834993 ;  36843923
S 473 D Colonic inflammation Phosphorylation 36735734
S 473 D Diabetes mellitus Phosphorylation 17130464 ;  16777975 ;  15033922 ;  15033922 ;  16777975 ;  17130464 ;  35739993
S 473 D Turner syndrome Phosphorylation 33910978
S 473 U Cardiomyopathy Phosphorylation 35358489
S 473 U Diabetes mellitus Phosphorylation 35358489
S 473 U Endometrial cancer/carcinoma Phosphorylation 16585156
S 473 U Melanoma Phosphorylation 26565903
S 473 U Non-small cell lung cancer Phosphorylation 35961388
S 473 U Hepatocellular carcinoma Phosphorylation 33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: